| Ingredient | Amount | % DV% Daily Value — how much of the recommended daily intake one serving provides, based on a 2,000 calorie diet. 100% = full daily need. Values over 100% are common for water-soluble vitamins (B, C) and generally safe. Values over 200% are highlighted. |
|---|---|---|
| Calories | 10 Calorie(s) | — |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Vitamin D | 20 mcg | 100% |
| Thiamine | 1.8 mg | 150% |
| Niacin | 25 mg | 156% |
| Vitamin B6 | 2.5 mg | 147% |
| Folate | 850 mcg DFE | 213% |
| Vitamin B12 | 7.5 mcg | 313% |
| Pantothenic Acid | 11 mg | 220% |
| Calcium | 40 mg | 3% |
| Iron | 0.6 mg | 3% |
| Magnesium | 230 mg | 55% |
| L-Citrulline | 6 Gram(s) | — |
| CarnoSyn | 3.2 Gram(s) | — |
| Caffeine Anhydrous | 300 mg | — |
| Rhodiola rosea L. extract | 200 mg | — |
| L-Theanine | 200 mg | — |
| Ashwagandha extract | 300 mg | — |
| Coffee fruit concentrate | 100 mg | — |
| Trans-Resveratrol | 75 mg | — |
| Black Pepper extract | 5 mg | — |
| L-Leucine | 2 Gram(s) | — |
| N-Acetyl L-Tyrosine | 1 Gram(s) | — |
Other ingredients: Natural and Artificial flavor, Citric Acid, Malic Acid, Calcium Silicate, Silicon Dioxide, Tartaric Acid, Sucralose, Red 40, Lecithin
This score evaluates label quality — dosage disclosure, transparency, cleanliness of inactive ingredients, and formula composition. It does not measure clinical efficacy, bioavailability, or third-party testing. Read full methodology
Same category, higher SupplementScore. Based on dosage transparency, label cleanliness, and formula quality.
The research summaries below are about the ingredients in general, drawn from published studies that often use different doses, forms, and populations than this product. A "strong" evidence rating for an ingredient does not mean this product will produce that effect — studied doses may be significantly higher or lower than what is contained here. Always verify doses against the Supplement Facts table above.
Primary structural component of bones. Adequate lifelong intake, combined with vitamin D, helps prevent osteoporosis — supported by extensive clinical evidence.
Essential for muscle contraction through calcium signaling.
May improve sleep quality, especially in older adults and those with low magnesium status.
60% of body magnesium is stored in bone. Essential for bone mineralization.
May reduce muscle cramps and support post-exercise recovery.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
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All scores are algorithmically generated from publicly available label data (NIH Dietary Supplement Label Database) and reflect label quality — not clinical efficacy, safety, or product quality. This page is not affiliated with or endorsed by ON Optimum Nutrition. If you represent this brand and believe any information is inaccurate, please contact us for a correction. Read full methodology
Alternatives are selected from the same category (Vitamin D) with a higher overall score. This is not a recommendation — always verify ingredients and dosages match your needs.
Essential cofactor for nucleotide synthesis and cell division.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Involved in neurotransmitter synthesis including serotonin and dopamine. Cofactor for over 100 enzyme reactions.
B6 is a cofactor in the transsulfuration pathway, converting homocysteine to cysteine. This is a separate pathway from the B12/folate remethylation route.
At pharmacological doses (1500-3000mg), niacin may improve HDL cholesterol. This effect is dose-dependent and not expected at typical supplement doses.
Essential coenzyme (NAD/NADP) in hundreds of metabolic reactions.
Iron supplementation is used to address iron deficiency. Should be taken under medical supervision as excess iron can be harmful.
Iron is essential for oxygen transport and cellular energy production.
Essential for calcium absorption. Deficiency leads to rickets in children and osteomalacia in adults — a well-established causal relationship.
May reduce risk of respiratory infections. Active area of research.
Some association between low vitamin D levels and depression, but evidence is inconsistent.
Multiple RCTs show cortisol reduction and improved stress/anxiety scores, primarily with standardized extracts (KSM-66, Sensoril) at 300-600mg/day.
Limited evidence for testosterone effects, primarily in stressed or subfertile men using KSM-66 extract. Results in healthy men are inconsistent.
May improve VO2 max, strength, and recovery. Typically studied at 300-600mg/day of standardized root extract (KSM-66 or equivalent).
Essential cofactor for pyruvate dehydrogenase and other enzymes in carbohydrate metabolism.
Multiple RCTs show cortisol reduction and improved stress/anxiety scores, primarily with standardized extracts (KSM-66, Sensoril) at 300-600mg/day.
Limited evidence for testosterone effects, primarily in stressed or subfertile men using KSM-66 extract. Results in healthy men are inconsistent.
May improve VO2 max, strength, and recovery. Typically studied at 300-600mg/day of standardized root extract (KSM-66 or equivalent).
No FDA warnings or recalls on file.