| Ingredient | Amount | % DV% Daily Value — how much of the recommended daily intake one serving provides, based on a 2,000 calorie diet. 100% = full daily need. Values over 100% are common for water-soluble vitamins (B, C) and generally safe. Values over 200% are highlighted. |
|---|---|---|
| Vitamin D | 1000 IU | 250% |
| Vitamin E | 30 IU | 100% |
| Thiamine | 5 mg | 333% |
| Riboflavin | 5 mg | 294% |
| Niacin | 20 mg | 100% |
| Vitamin B6 | 20 mg | 1000% |
| Folic Acid | 400 mcg | 100% |
| Vitamin B12 | 25 mcg | 417% |
| Calcium | 100 mg | 10% |
| Phosphorus | 50 mg | 5% |
| Selenium | 70 mcg | 100% |
| Chromium | 120 mcg | 100% |
| Black Cohosh extract | 80 mg | — |
| Isoflavones | 80 mg | — |
| Estroblend(TM) | 400 mg | — |
| Cranberry extract | 300 mg | — |
| Boron | 1.5 mg | — |
Other ingredients: Dicalcium Phosphate, Non-GMO Kudzu Extract, Cellulose, Calcium Carbonate, Black Cohosh extract, Croscarmellose, Green Tea extract, Crospovidone, Boron Amino Acid Chelate, D-Alpha-Tocopheryl Acid Succinate, Pyridoxine Hydrochloride, Cranberry Extract, Polyvinyl Alcohol, Niacinamide, Silicon Dioxide, Stearic Acid, Polyethylene Glycol, Magnesium Silicate, Sodium Selenate, Titanium Dioxide color, Thiamine Mononitrate, Vegetable Magnesium Stearate, Riboflavin, FD&C Yellow #5 Lake, Magnolia bark powder, Starch, Non-GMO Soy Extract, Chromium Amino Acid Chelate, Date seed extract, Cinnamon extract, Folic Acid, FD&C Red #40 Lake, Polysorbate 80, Cyanocobalamin, Cholecalciferol
This score evaluates label quality — dosage disclosure, transparency, cleanliness of inactive ingredients, and formula composition. It does not measure clinical efficacy, bioavailability, or third-party testing. Read full methodology
Same category, higher SupplementScore. Based on dosage transparency, label cleanliness, and formula quality.
The research summaries below are about the ingredients in general, drawn from published studies that often use different doses, forms, and populations than this product. A "strong" evidence rating for an ingredient does not mean this product will produce that effect — studied doses may be significantly higher or lower than what is contained here. Always verify doses against the Supplement Facts table above.
Primary structural component of bones. Adequate lifelong intake, combined with vitamin D, helps prevent osteoporosis — supported by extensive clinical evidence.
Essential for muscle contraction through calcium signaling.
Essential for red blood cell formation. Deficiency causes megaloblastic anemia, confirmed by decades of clinical evidence.
Involved in myelin synthesis and nerve function. Adequate B12 status supports neurological health, particularly in older adults and vegans.
Cofactor in energy production pathways, but supplementation only helps if deficient.
Involved in neurotransmitter synthesis including serotonin and dopamine. Cofactor for over 100 enzyme reactions.
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All scores are algorithmically generated from publicly available label data (NIH Dietary Supplement Label Database) and reflect label quality — not clinical efficacy, safety, or product quality. This page is not affiliated with or endorsed by up&up. If you represent this brand and believe any information is inaccurate, please contact us for a correction. Read full methodology
Alternatives are selected from the same category (Vitamin D) with a higher overall score. This is not a recommendation — always verify ingredients and dosages match your needs.
B6 is a cofactor in the transsulfuration pathway, converting homocysteine to cysteine. This is a separate pathway from the B12/folate remethylation route.
Protects polyunsaturated fatty acids in cell membranes from oxidation.
May help protect skin from UV damage when combined with vitamin C.
At 400mg/day (far above RDA of 1.3mg), riboflavin may reduce migraine frequency. Effect is dose-dependent and not expected at typical supplement doses.
At pharmacological doses (1500-3000mg), niacin may improve HDL cholesterol. This effect is dose-dependent and not expected at typical supplement doses.
Essential coenzyme (NAD/NADP) in hundreds of metabolic reactions.
Essential for calcium absorption. Deficiency leads to rickets in children and osteomalacia in adults — a well-established causal relationship.
May reduce risk of respiratory infections. Active area of research.
Some association between low vitamin D levels and depression, but evidence is inconsistent.
Essential cofactor for pyruvate dehydrogenase and other enzymes in carbohydrate metabolism.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
Adequate folate intake before and during early pregnancy reduces risk of neural tube defects. This is one of the most well-established findings in nutrition.
Essential cofactor for nucleotide synthesis and cell division.
No FDA warnings or recalls on file.